https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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‘Certainly, which is about right. I seek out a Actual physical knowledge of Organic systems in the base-up way. I think you could possibly distinguish a few traces of investigate in my group in the intervening time. The initial problems chromosome structure: How can you get yourself a metre-extensive DNA polymer folded and organised in such a microscopic cell? Now we have developed visualisation strategies that make it possible for us to check how, for instance, SMC proteins loop DNA (video clip on Youtube) in order to Develop up chromosomes.
1996, 1st mesoscopic demand density waves gadgets; and initially electrical measurements on a single steel nanocluster concerning nanoelectrodes
‘It had been just a issue of selecting up a ebook on cell biology and beginning to browse. I'd originate from a planet of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing the job at place temperature with molecular biology kits.
Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand moments in the reliable condition nanopore
That could be a dream of mine and we set to operate with a delightful dose of naivety. This is a thing that will most likely yield impressive results in the for a longer time time period, but that does not issue. You shouldn't only want to operate within the issues of tomorrow, but also within the issues of the day soon after tomorrow.’
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look under on the spectrum of our existing tasks.
Lots of related developments followed, exactly where our group set up distinct transistor variants for example solitary-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into compact evidence-of-theory Digital circuits.
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, as well as a 3D rendering of the motion of the DNA rod is shown.
Imagine if, as opposed to using regular best-down silicon electronics, transistors might be built from the bottom up using solitary organic molecules as being the switching components? This concept, which turned The idea of now’s discipline of molecular electronics, first emerged while in the 1970s.
Resolving the step size in condensin-pushed DNA loop extrusion identifies ATP binding because the step-producing procedure
‘The idea that There exists this kind of thing like a starting, a giant bang, is already an interesting signpost to take into consideration that there was a creator. But extra usually, and on The idea of pure rationality, I also arrive at a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are only atoms and all-natural forces that we will measure.
‘That problems the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter seemed top-down in People times and identified about 5 hundred genes which have been ceesdekker.net minimally necessary for just a working mobile. We wish to appear base-up: how can we move from a several molecules to a complete biological process?
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
Solid-state nanopores have proven to become a remarkably flexible probe for single-molecule Evaluation of DNA. I will describe some of our recent findings – specifically DNA knots – as well as our efforts to expand the abilities of good-point out nanopores even even further, from the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.